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pentobarbital will minimize the level or result of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some lessen in fentanyl plasma concentrations, lack of efficacy or, quite possibly, growth of the withdrawal syndrome in a affe